WebBAP1 – The most frequently mutated DUB in human cancers BAP1, which stands for BRCA1 associated protein 1, is a DUB with tumor suppressive function 47,48. BAP1 is a UCH family deubiquitinase that was originally described as being exclusively nuclear 49 , although more recent studies have shown that it has important functions in the cytoplasm … WebJun 30, 2024 · Full-length human BAP1 protein expressed and purified from E.coli ... Target Specificity . Reacts with human BAP1 protein. Not tested in other species. Name. Ubiquitin carboxyl-terminal hydrolase BAP1. Product type. Primary antibodies. Clonality. Monoclonal antibody. Isotype ...
Therapeutic Targeting of BAP1/ASXL3 Sub-Complex in SCLC
WebJan 18, 2024 · BAP1 mutant mesothelioma tumors have a poor prognosis and few therapeutic options. Here, Pandey and Landman et al. show that the combined targeting … WebJul 1, 2024 · BRCA-associated protein 1 (BAP1) is one of the molecular targets that has been identified as a potential novel target in the treatment of MM. BAP1 has a number of … light rail to fair park in dallas
Carolina Navas Cuerva - Scientific Advisor - IQVIA LinkedIn
WebNov 5, 2024 · Background BRCA-1 associated protein (BAP1) is a de-ubiquitinating enzyme that regulates gene expression. Recently, the BAP1 mutation and its involvement in … WebSome UM cases occur in families with an inherited predisposition for UM. The only high-penetrance susceptibility gene for familial UM identified so far is BRCA1-associated protein 1 (BAP1).The frequency of predicted pathogenic germline BAP1 mutations observed in different cohorts of UM patients ranges from 1.6% to 3%, with mutations predominantly … WebShowing subcellular location of BAP1 (hucep-6, KIAA0272, UCHL2). We use cookies to enhance the usability of our website. ... GO:1903955 [positive regulation of protein … medical term for heavy menstrual cycle