WebJan 12, 2024 · Gemcitabine is the first-line chemotherapy drug for cholangiocarcinoma (CCA), but acquired resistance has been frequently observed in CCA patients. To search for potential long noncoding RNAs (lncRNAs) involved in gemcitabine resistance, two gemcitabine resistant CCA cell lines were established and dysregulated lncRNAs were … WebJan 11, 2024 · Often chemotherapy is not used to cure the cancer, instead it is a palliative treatment. This means that it is used to manage side effects and improve your quality of …
Efficacy of FGFR Inhibitors and Combination Therapies …
WebAug 3, 2016 · Abstract. Activation of checkpoint arrest and homologous DNA repair are necessary for maintenance of genomic integrity during DNA replication. Germ-line mutations of the ataxia telangiectasia mutated (ATM) gene result in the well-characterized ataxia telangiectasia syndrome, which manifests with an increased cancer predisposition, … WebJan 1, 2024 · CCA is largely resistant to systemic chemotherapy and prognosis of patients with advanced disease remains poor [14, 15]. However, several recent reports have identified key oncogenic drivers as possible therapeutic targets in CCA patients, and a wide number of agents have been assessed and are currently under investigation [16] , [17] , … blink franchising
Chemoresistance and resistance to targeted therapies in biliary …
WebCholangiocarcinoma can arise in all parts of the biliary tract and this has implications for therapy. Surgery is the mainstay of therapy however local relapse is a major problem. … WebInfigratinib (BGJ398) in previously treated patients with advanced or metastatic cholangiocarcinoma with FGFR2 fusions or rearrangements: mature results from a … WebCholangiocarcinoma (CCA) can resist chemotherapy resulting in treatment failure. Gemcitabine, a chemotherapeutic drug, can sensitize cancer cells to become susceptible to cytotoxic T-lymphocytes (CTLs). We, therefore, hypothesized that a combination of gemcitabine and CTLs would be more effective for CCA treatment than individual therapy. fred priebe obituary