Signal regulatory protein alpha
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons. SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don't eat me" signal. This interaction … See more The cytoplasmic region of SIRPα is highly conserved between rats, mice and humans. Cytoplasmic region contains a number of tyrosine residues, which likely act as ITIMs. Upon CD47 ligation, SIRPα is phosphorylated and … See more SIRPα recognizes CD47, an anti-phagocytic signal that distinguishes live cells from dying cells. CD47 has a single Ig-like extracellular domain and five membrane spanning regions. The interaction between SIRPα and CD47 can be modified by endocytosis or … See more • Oldenborg PA (2013). "CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease". … See more The extracellular domain of SIRP α binds to CD47 and transmits intracellular signals through its cytoplasmic domain. CD47-binding is mediated … See more Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. In one study, they engineered high-affinity variants of SIRP α that antagonized CD47 on cancer cells and caused increase phagocytosis of cancer cells. Another study … See more WebApr 10, 2024 · Karyopherin subunit alpha 1 (KPNA1), also known as importin alpha 5 in human, is a cytoplasmic protein belonging to the importin alpha family and is involved in nuclear protein import [9, 10]. KPNA1 is ubiquitously expressed in brain, testis, and 25 other tissues, and the previous studies emphasized its effects on neuronal differentiation and …
Signal regulatory protein alpha
Did you know?
WebNov 14, 2024 · Temporal regulation of microglia phagocytosis is central to nervous system development, but the underlying mechanisms for this regulation remain poorly … WebApr 13, 2024 · The shedding of cell surface receptors may bring synergistic outcomes through the loss of receptor-mediated cell signaling and competitive binding of the shed …
WebJan 16, 2024 · Signal regulatory protein-α (SIRPA/SIRPα) is a transmembrane protein that is expressed in various tissues, including the heart. Previous studies have demonstrated … http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_PM8649784
WebCC-95251 is a novel, fully human immunoglobulin G1 antibody (Ab) that binds to SIRPα on macrophages to potently block the CD47–SIRPα interaction. Aims. The primary objectives … WebCD47 is a “don’t eat me” signal to phagocytes that is overexpressed on many tumor cells as a potential mechanism for immune surveillance evasion. CD47 and its interaction with signal-regulating protein alpha (SIRPα) on phagocytes is therefore a promising cancer target. Therapeutic antibodies and fusion proteins that block CD47 or SIRPα have been …
WebThe signal regulatory protein-β1 (SIRPβ1) is a DAP12-associated transmembrane receptor expressed in a subset of hematopoietic cells. Recently, it was shown that peritoneal …
WebApr 13, 2024 · The shedding of cell surface receptors may bring synergistic outcomes through the loss of receptor-mediated cell signaling and competitive binding of the shed soluble receptor to its ligand. Thus, soluble receptors have both biological importance and diagnostic importance as biomarkers in immunological disorders. Signal regulatory … impala brown metallic 441uWebJun 7, 2024 · Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that … impala bolt and nut pty ltdWebMay 19, 2024 · Signal regulatory protein alpha (SIRPα) is a type I transmembrane protein with three extracellular Ig-like domains and two cytoplasmic immunoreceptor tyrosine … impala bunny bun twitterWebSpeed is critical in responding to a novel pathogen. Our cross-functional task force is developing products, processes and infrastructure to bolster our long-term preparedness … impala brothers alden nyWebActivation of transcription factor NF-kappaB involves signal-induced degradation of the protein inhibitor IkappaB-alpha and release of NF-kappaB which translocates to the nucleus where it influences transcription of responsive genes. Although multiple regions of IkappaB-alpha are involved in this process, the N-terminal region of the protein has been identified … impala bucket seats for saleWebアズワンの【AXEL】85-7748-04 SIRPA (BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP, Tyrosine-protein Phosphatase Non-receptor Type Substrate 1, Brain Ig-like Molecule with Tyrosine-based Activation Motifs, CD172 Antigen-like Family Member A, Inhibitory Receptor SHPS-1, Macrophage Fusion Receptor, MyD-1 Antigen, Signal-regulatory Protein alpha-1, Signal … impala buildersWebNov 30, 2024 · Signal regulatory protein α (SIRPα) is a myeloid-lineage inhibitory receptor that restricts innate immunity through engagement of its cell surface ligand CD47. Blockade of the CD47–SIRPα interaction synergizes with tumor-specific antibodies and T-cell checkpoint inhibitors by promoting myeloid-mediated antitumor functions leading to the … impala build from source